Condition: Chronic Myeloid Leukemia · Sponsor: University Hospital, Bordeaux
Treatment of chronic myeloid leukemia (CML) has been revolutionized by tyrosine kinase inhibitor (TKI). Nevertheless, case of failure and suboptimal response are still observed even in children. Pediatric CML is a rare disease and differs from adult in terms of disease presentation and treatment response underlying a likely different CML biology. Molecular mechanisms that induce resistance to TKI are still poorly characterized except mutations in the tyrosine kinase domain of BCR::ABL1. We propose to search for a molecular signature to predict the response to TKI in the pediatric population.
This description comes directly from the study's public registry record.
Stéphanie DULUCQ · 05 57 82 14 98 · stephanie.dulucq@chu-bordeaux.fr
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| CHU de Bordeaux, Service Hématologie Biologique | Bordeaux, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05605379