● Recruiting

Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial)

Condition: Carcinoma, Ovarian Epithelial · Low Grade Serous Adenocarcinoma of Ovary · Sponsor: Ente Ospedaliero Ospedali Galliera

PhasePhase 3

Planned participants132

Who can joinFemale, 18 Years to no upper limit

Healthy volunteersNo

About this study

This is an Italian, multicenter, randomized, open-label phase III trial which will evaluate if Letrozole is superior to standard adjuvant chemotherapy in patients with hormone receptor positive low-grade serous epithelial carcinoma of the ovary (LGSCO). The hypothesis is that letrozole will significantly prolong median progression free survival (PFS) compared with the standard chemotherapy treatment, namely carboplatin AUC 5 and paclitaxel 175 mg/m2.

This description comes directly from the study's public registry record.

Talk to the study team

Andrea DeCensi, Prof. · +39(0)105634501 · andrea.decensi@galliera.it

Marianna Fava, PhD · +39(0)105634580 · marianna.fava@galliera.it

Always discuss trial participation with your own doctor first.

Locations (19)

Ospedale San Donato	Arezzo, AR, Italy	Recruiting
Ospedale degli Infermi	Ponderano, BI, Italy	Recruiting
Ospedale San Martino	Belluno, BL, Italy	Recruiting
Fondazione Poliambulanza	Brescia, BS, Italy	Recruiting
ASST degli Spedali Civili di Brescia	Brescia, BS, Italy	Recruiting
Ospedale Sant'Anna	Como, CO, Italy	Recruiting
IRST	Meldola, FC, Italy	Recruiting
AOU Ferrara	Ferrara, FE, Italy	Recruiting
Medical Oncology Division, Ente Ospedaliero Ospedali Galliera	Genova, Genova, Italy	Recruiting
Fondazione IRCCS Istituto Nazionale dei Tumori	Milan, MI, Italy	Recruiting
IEO	Milan, MI, Italy	Recruiting
IRCCS Istituto Oncologico Veneto	Padua, PD, Italy	Recruiting

+ 7 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05601700