Condition: Aging · Frailty · Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital
A severe public health issue facing global population is aging. Increasing preclinical and clinical data indicate the contribution of gut microbiome on aging and aging-related diseases such as cardiovascular disease, Alzheimer Disease, and diabetes. Interventions on microbiota are developed including prebiotics, probiotics, and fecal microbial transplantation (FMT). FMT via oral capsules also advances in recent with limited safety concerns compared with invasive routes. A hypothesis is thus raised that gut microbiome intervention via oral FMT can be a potential safe approach to encourage healthy aging, with multiple aspects evaluated for clinical phenotype of frailty, anthropometric measurement, cognitive function, cardiovascular aging, physical function, living activity, hippocampal volume, telomere length, cognitive biomarkers, inflammatory biomarkers, altered microbial composition and metabolites.
This description comes directly from the study's public registry record.
Luyun Fan, MD,PhD · 01081992131 · katevan@163.com
Jun Cai, MD,PhD · caijun7879@126.com
Always discuss trial participation with your own doctor first.
| Beijing Chao-yang Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Recruiting |
| Beijing Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Chinese People's Liberation Army (PLA) General Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Xuanwu Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Recruiting |
| Huadong Hospital Affiliated to Fudan University | Shanghai, Shanghai Municipality, China | Recruiting |
| Zhejiang Hospital | Hangzhou, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05598112