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Study identifier: NCT05597345 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Selinexor for the Treatment of Intermediate and High-Risk Smoldering Multiple Myeloma

Condition: Smoldering Multiple Myeloma  ·  Sponsor: University of Rochester

PhasePhase 2
Planned participants15
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Selinexor is a drug that has been approved in the treatment of patients with symptomatic multiple myeloma. The standard of care for patients with Smoldering Multiple Myeloma remains observation, but there are numerous clinical trials investigating interventions to delay progression to multiple myeloma and prevent or delay disease related outcomes. A subset of patients with intermediate or high risk smoldering multiple myeloma have a much higher risk of progressive to multiple myeloma, while the low risk smoldering myeloma patient population has a much lower risk. This is a clinical trial investigating the use of low-dose selinexor in patients with intermediate to high-risk smoldering multiple myeloma. The investigators hypothesize that the use of selinexor in intermediate to high risk smoldering myeloma patients will help to delay progression of disease to symptomatic multiple myeloma.

This description comes directly from the study's public registry record.

Talk to the study team

Jodi Lipof  ·  6505042400  ·  jodi_lipof@urmc.rochester.edu

Brea Lipe  ·  Brea_Lipe@urmc.rochester.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of RochesterRochester, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05597345