Condition: Aging · Alzheimer Disease · Healthy Aging · Sponsor: Rutgers, The State University of New Jersey
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question\[s\] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Balance (SFB) intervention on a cognitive marker of Alzheimer's risk, generalization? * What is the effect of the CDF vs. SFB intervention on a fMRI biomarker of Alzheimer's, neural flexibility, and do improvements in neural flexibility mediate improvements in generalization? * Do ABCA7 genotypic variations moderate the efficacy of the CDF vs. SFB intervention for reducing Alzheimer's risk? Participants will undergo-- at baseline and post-test-- health assessments, cognitive tests, and structural and functional magnetic resonance imaging (fMRI), and a blood-draw to assess Alzheimer's risk biomarker levels.
This description comes directly from the study's public registry record.
Bernadette A. Fausto, PhD · (973) 944-0775 · bernadette.fausto@rutgers.edu
Jennifer Greene, MPH · (973) 353-2257 · jag644@rutgers.edu
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| Rutgers, The State University of New Jersey - Newark campus | Newark, New Jersey, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05597124