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Study identifier: NCT05593549 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

Condition: Type 2 Diabetes · Healthy Aging  ·  Sponsor: Medical College of Wisconsin

PhaseEARLY_Phase 1
Planned participants60
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.

This description comes directly from the study's public registry record.

Talk to the study team

William Hughes, Ph.D.  ·  414-955-7519  ·  whughes@mcw.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Medical College of WisconsinMilwaukee, Wisconsin, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05593549