Condition: Breast Cancer · Breast Cancer Recurrent · Sponsor: University Health Network, Toronto
Breast-conserving surgery followed by re-irradiation with partial breast irradiation (rPBI) has recently been found to be a safe alternative to mastectomy for women who have undergone prior whole breast radiation. By reducing the volume of tissue receiving radiation, rPBI has been associated with less toxicity and improved cosmetic outcomes. For many women with early-stage breast cancer, shorter 1-week (5-fraction) courses of breast radiation (ultra-fractionation) have been found to be equivalent to longer fractionation schedules in the upfront treatment setting. These 1-week schedules are more convenient for patients, with fewer treatments and shorter overall treatment time. The investigators hypothesize that a 1-week ultra-hypofractionated rPBI regimen following breast-conserving surgery (BCS) for local recurrence or new primary breast cancer in the previously irradiated breast (LR) will be associated with acceptable toxicity at 1 year (\<13% grade \>3 toxicity).
This description comes directly from the study's public registry record.
Danielle Rodin, MD · (416) 946-6513 · danielle.rodin@uhn.ca
Anne Koch, MD · (416) 946-2919 · anne.koch@uhn.ca
Always discuss trial participation with your own doctor first.
| NYU Langone Health | New York, New York, United States | Recruiting |
| Columbia University Medical Center | New York, New York, United States | Recruiting |
| Virgina Community University Massey Comprehensive Cancer Center | Richmond, Virginia, United States | Recruiting |
| Peter MacCallum Cancer Centre | Melbourne, Victoria, Australia | Recruiting |
| A.C.Camargo Cancer Center | São Paulo, São Paulo, Brazil | Recruiting |
| Royal Victoria Regional Health Centre | Barrie, Ontario, Canada | Recruiting |
| London Health Science Centre - Verspeeten Family Cancer Centre | London, Ontario, Canada | Recruiting |
| Lakeridge Health | Oshawa, Ontario, Canada | Recruiting |
| Odette Cancer Centre | Toronto, Ontario, Canada | Recruiting |
| Princess Margaret Cancer Centre | Toronto, Ontario, Canada | Recruiting |
| CHU de Québec-Université Laval | Montreal, Quebec, Canada | Recruiting |
| Hôpital Maisonneuve-Rosemont - CIUSSS de l'Est-de-l'Île-de-Montréal | Montreal, Quebec, Canada | Recruiting |
+ 7 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05592938