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Study identifier: NCT05587894 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial

Condition: COVID-19 · Immunodeficiency  ·  Sponsor: ANRS, Emerging Infectious Diseases

PhasePhase 2
Planned participants256
Who can joinAll sexes, 16 Years to no upper limit
Healthy volunteersNo

About this study

The overall purpose of the trial is to evaluate the efficacy and safety of possible combination antiviral therapy DAA (remdesivir + nirmatrelvir/r)∞ versus the reference monotherapy (nirmatrelvir/r alone) and to assess the efficacy and safety of increasing the nirmatrelvir/r course from 5- to 10 days in immunocompromised patients diagnosed with asymptomatic or mild to moderate COVID-19.

This description comes directly from the study's public registry record.

Talk to the study team

Douae Ammour  ·  +33782960531  ·  douae.ammour@inserm.fr

Chiara Fedeli  ·  +41 (0)22 372 9817  ·  chiara.fedeli@hug.ch

Always discuss trial participation with your own doctor first.

Locations (18)

Saint-André HospitalBordeaux, Bordeaux, FranceRecruiting
Pellegrin HospitalBordeaux, Bordeaux, FranceRecruiting
Francois Mitterrand HospitalDijon, Dijon, FranceRecruiting
Croix Rousse HospitalLyon, Lyon, FranceRecruiting
La Colombière HospitalMontpellier, Montpellier, FranceRecruiting
Hotel Dieu HospitalNantes, Nantes, FranceRecruiting
Laribosière HospitalParis, Paris, FranceRecruiting
Saint Antoine HospitalParis, Paris, FranceRecruiting
Pitié-Salpêtrière HospitalParis, Paris, FranceRecruiting
Saint Louis HospitalParis, Paris, FranceRecruiting
Bichat Claude-Bernard HospitalParis, Paris, FranceRecruiting
Robert Debré HospitalReims, Reims, FranceRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05587894