Condition: Upper GI Bleeding · Proton Pump Inhibitors · Sponsor: Chinese University of Hong Kong
Vonoprazan (VPZ), an oral potassium-competitive acid blocker (P-CAB) has emerged as an alternative potent acid-suppressant.It has a faster onset of action in 1 day (3-5 days in PPI), and is more stable in acidic condition than PPI. While many studies compared Vonoprazan against PPI in the treatment of reflux oesophagitis, H. Pylori eradication, and gastric ulcers; thus far, there is a paucity of data on use of Vonoprazan on bleeding peptic ulcers. We perform a multicenter randomized controlled trial (RCT) to compare the efficacy of oral Vonoprazan against standard high dose PPI therapy in bleeding peptic ulcers that had received successful endoscopic haemostasis We hypothesize that in patients with bleeding peptic ulcers, the use of acid pump inhibitors Vonoprazan would not be inferior to standard treatment of a bolus plus high dose PPI intravenous infusion at preventing recurrent bleeding after endoscopic haemostasis.
This description comes directly from the study's public registry record.
xiaobei luo, PhD · 86 17688881428 · luoxiaobei63@126.com
bingyee suen, Bachelor · 35052640 · bingyeesuen@surgery.cuhk.edu.hk
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| Nanfang Hospital Southern Medical University | Guangzhou, Guangdong, China | Recruiting |
| The Second Affiliated Hospital of Guangzhou Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The Second Affiliated Hospital of Guangzhou University of Chinese Medicine | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Shenzhen Pingshan District People's Hospital | Shenzhen, Guangdong, China | Not Yet Recruiting |
| The Second Affiliated Hospital The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen | Shenzhen, Guangdong, China | Not Yet Recruiting |
| Yangjiang People's Hospital of Guangdong Medical University | Yangjiang, Guangdong, China | Not Yet Recruiting |
| Zhuhai People's Hospital (Zhuhai Hospital Affiliated to Jinan University) | Zhuhai, Guangdong, China | Not Yet Recruiting |
| Prince of Wales Hospital | Hong Kong, Hong Kong SAR, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05582174