Condition: Locally Advanced or Metastatic Solid Tumors · NSCLC · HNSCC · Sponsor: Genentech, Inc.
This is a first-in-human study to evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of enzelkitug when administered as a single agent and in combination with atezolizumab or pembrolizumab in adult participants with locally advanced or metastatic solid tumors, including non small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), melanoma, triple-negative breast cancer (TNBC), esophageal cancer, gastric cancer, cervical cancer, colorectal cancer (CRC), urothelial carcinoma (UC), clear cell renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Participants will be enrolled in 2 stages: dose escalation and dose expansion.
This description comes directly from the study's public registry record.
Reference Study ID Number: GO43860 https://forpatients.roche.com/ · 888-662-6728 (U.S. Only) · global-roche-genentech-trials@gene.com
Fastest response: use the inquiry form. No email attachments https://www.gene.com/contact-us/submit-medical-inquiry
Always discuss trial participation with your own doctor first.
| Stanford University | San Francisco, California, United States | Recruiting |
| University Of Colorado | Aurora, Colorado, United States | Recruiting |
| Florida Cancer Specialists - Sarasota | Sarasota, Florida, United States | Recruiting |
| Winship Cancer Institute | Atlanta, Georgia, United States | Completed |
| Dana Farber Cancer Institute | Boston, Massachusetts, United States | Recruiting |
| Henry Ford Hospital | Detroit, Michigan, United States | Recruiting |
| Washington University Medical Center, Division of Oncology | St Louis, Missouri, United States | Completed |
| Rutgers Cancer Institute of New Jersey | New Brunswick, New Jersey, United States | Recruiting |
| The West Clinic - Memphis (Union Ave) | Germantown, Tennessee, United States | Recruiting |
| SCRI Oncology Partners | Nashville, Tennessee, United States | Recruiting |
| IDS (IDS) Pharmacist South Texas Accelerated Resear Therapeutics, LLC START | San Antonio, Texas, United States | Recruiting |
| Kinghorn Cancer Centre | Darlinghurst, New South Wales, Australia | Recruiting |
+ 29 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05581004