Condition: Acute Myeloid Leukemia · Sponsor: Assistance Publique - Hôpitaux de Paris
Acute myeloid leukemia (AML) is a heterogeneous clonal myeloid neoplasm where abnormal proliferation and impaired differentiation of hematopoietic stem and myeloid progenitor cells impedes normal hematopoiesis. Sulfasalazine (SSZ) is a broadly available, well tolerated anti-inflammatory medicine approved for the treatment of ulcerative colitis and rheumatoid arthritis. Intact SSZ, but not its metabolites 5-aminosalicylic acid and sulfapyridine, competitively inhibits xCT.21 SSZ is thus an ideal candidate for drug repurposing in AML.The purpose of this phase I study is to evaluate the safety and feasibility of such strategy, provide preliminary signals of efficacy, and identify potential biomarkers
This description comes directly from the study's public registry record.
Raphaël Itzykson, Pr · 1 42 49 96 43 · raphael.itzykson@aphp.fr
Jérôme Lambert, Pr · 142499742 · jerome.lambert@u-paris.fr
Always discuss trial participation with your own doctor first.
| CHU Amiens | Amiens, France | Not Yet Recruiting |
| Hôpital Avicenne | Bobigny, France | Not Yet Recruiting |
| CHU Caen | Caen, France | Not Yet Recruiting |
| CHU Henri Mondor | Créteil, France | Recruiting |
| Centre Hospitalier Lyon Sud, Lyon | Lyon, France | Recruiting |
| Hôpital de la Conception, AP-HM | Marseille, France | Not Yet Recruiting |
| CHU Nice | Nice, France | Recruiting |
| AP-HP Hôpital Saint Louis | Paris, France | Recruiting |
| AP-HP Hôpital Cochin | Paris, France | Recruiting |
| Centre Henri Becquerel | Rouen, France | Not Yet Recruiting |
| CHU Tours | Tours, France | Recruiting |
| CH Mignot | Versailles, France | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05580861