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Study identifier: NCT05579132 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Clinical Study of MK-1045 (CN201) in People With Precursor B-cell Acute Lymphoblastic Leukemia (MK-1045-002)

Condition: Acute Lymphoblastic Leukemia  ·  Sponsor: MSD R&D (China) Co., Ltd.

PhasePhase 1/Phase 2
Planned participants203
Who can joinAll sexes, 2 Years to no upper limit
Healthy volunteersNo

About this study

Researchers are looking for new ways to treat people with a type of blood cancer called precursor B-cell Acute Lymphoblastic Leukemia (B-ALL) that is relapsed- the cancer has come back after treatment, or refractory - the current treatment has stopped working to slow or stop cancer growth. This study will have two parts. In the first part (dose escalation phase) the goal is to learn about the safety of a study treatment, MK-1045, and to find the best dose level of MK-1045 that is tolerated and may work to treat B-ALL. In the second part (Phase II) researchers want to learn how well MK-1045 works to treat B-ALL.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (11)

The Second Affiliated Hospital of Third Military Medical University ( Site 0008)Chongqing, Chongqing Municipality, ChinaRecruiting
Southern Medical University Nanfang Hospital ( Site 0004)Guangzhou, Guangdong, ChinaRecruiting
The Second Hospital of Hebei Medical University ( Site 0003)Shijiazhuang, Hebei, ChinaRecruiting
The First Hospital of Harbin ( Site 0005)Harbin, Heilongjiang, ChinaRecruiting
Henan Cancer Hospital-hematology department ( Site 0002)Zhengzhou, Henan, ChinaRecruiting
Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology ( Site 0010)Wuhan, Hubei, ChinaRecruiting
Tongji Hospital affiliated to Tongji Medical College of HUST ( Site 0006)Wuhan, Hubei, ChinaRecruiting
The Affiliated Hospital of Xuzhou Medical University ( Site 0007)Xuzhou, Jiangsu, ChinaActive Not Recruiting
West China Second University Hospital, Sichuan University ( Site 0011)Chengdu, Sichuan, ChinaCompleted
Hematology Hospital of Chinese Academy of Medical Sciences ( Site 0001)Tianjin, Tianjin Municipality, ChinaRecruiting
The Children's Hospital of Zhejiang University School of Medicine ( Site 0009)Hangzhou, Zhejiang, ChinaCompleted

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Source record: clinicaltrials.gov/study/NCT05579132