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Study identifier: NCT05577754 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Assessment of the Efficacy and Safety of Alpelisib (BYL719) in Pediatric and Adult Patients With Megalencephaly-CApillary Malformation Polymicrogyria Syndrome (MCAP)

Condition: Megalencephaly-capillary Malformation Polymicrogyria Syndrome (MCAP)  ·  Sponsor: Centre Hospitalier Universitaire Dijon

PhasePhase 2
Planned participants20
Who can joinAll sexes, 2 Years to 40 Years
Healthy volunteersNo

About this study

This study is a two periods multi-center Phase II trial, with a 6 months double-blind, placebo-controlled period followed by open label period, to assess the efficacy and safety of alpelisib (BYL719) in pediatric and adult patients with Megalencephaly-CApillary malformation Polymicrogyria syndrome (MCAP)

This description comes directly from the study's public registry record.

Talk to the study team

Laurence OLIVIER-FAIVRE  ·  0380295313  ·  laurence.faivre@chu-dijon.fr

Always discuss trial participation with your own doctor first.

Locations (13)

CHU AmiensAmiens, FranceRecruiting
CHU d'AngersAngers, FranceRecruiting
CHRU BrestBrest, FranceNot Yet Recruiting
HCL - Groupement Hospitalier Est Hôpital Femme-Mère-EnfantBron, FranceRecruiting
Chu EstaingClermont-Ferrand, FranceRecruiting
Chu Dijon BourgogneDijon, FranceRecruiting
CHU Dijon Bourgogne - CIC-PDijon, FranceActive Not Recruiting
CHU de LilleLille, FranceRecruiting
CHRU NîmesNîmes, FranceRecruiting
AP-HP Hôpital Necker-Enfants Malades - CICParis, FranceActive Not Recruiting
AP-HP Hôpital Necker-Enfants MaladesParis, FranceRecruiting
CHU RennesRennes, FranceRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05577754