Condition: Rectal Cancer · Locally Advanced · Sponsor: Ruijin Hospital
The goal of this phase 2 study is to learn about the efficacy and safety of short-course radiotherapy (SCRT) sequential Penpulimab in combination with CAPEOX in the neoadjuvant treatment of microsatellite stable (MSS) locally advanced rectal cancer. The main question it aims to answer is the role of immune checkpoint inhibitors in the neoadjuvant treatment of MSS rectal cancer. Participants will receive neoadjuvant treatment of SCRT sequential Penpulimab in combination with CAPEOX. Participants will undergo a clinical re-staging assessment at the end of neoadjuvant therapy to determine whether to adopt a watch-and-wait strategy or undergo radical surgery.
This description comes directly from the study's public registry record.
Ren Zhao, MD, PHD · +8618917762018 · zhaorensurgeon@aliyun.com
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| Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine | Shanghai, None Selected, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05576480