Condition: Aging · Alzheimer Disease · Sponsor: Virginia Polytechnic Institute and State University
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.
This description comes directly from the study's public registry record.
Tae-Ho Lee, PhD · 540-231-6174 · taehol@vt.edu
Benjamin Katz, PhD · 540-231-9816 · katzben@vt.edu
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| Virginia Polytechnic Institute and State University | Blacksburg, Virginia, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05574634