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Study identifier: NCT05574296 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Hydrogen's Feasibility and Safety as a Therapy in ECPR

Condition: Cardiac Arrest · Extracorporeal Membrane Oxygenation · Reperfusion Injury  ·  Sponsor: Boston Children's Hospital

PhasePhase 1
Planned participants53
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients undergoing refractory cardiac arrest in the cardiac ICU at a participating center will be randomized to standard therapy with or without the administration of 2% hydrogen in gases administered via the ventilator and ECMO membrane for 72 hours.

This description comes directly from the study's public registry record.

Talk to the study team

John N Kheir, MD  ·  8576368890  ·  john.kheir@childrens.harvard.edu

Victoria Habet, DO

Always discuss trial participation with your own doctor first.

Locations (4)

Children's National HospitalWashington D.C., District of Columbia, United StatesNot Yet Recruiting
Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Children's Mercy Kansas CityKansas City, Missouri, United StatesNot Yet Recruiting
Primary Children's HospitalSalt Lake City, Utah, United StatesNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT05574296