Condition: Metastatic Lung Non-Small Cell Carcinoma · Recurrent Lung Non-Small Cell Carcinoma · Stage IIIC Lung Cancer AJCC v8 · Sponsor: University of Washington
This phase II trial tests whether CXCR1/2 inhibitor SX-682 (SX-682) with pembrolizumab works to treat patients with stage IIIC or IV non-small cell lung cancer that has spread to other parts of the body (metastatic) or that has come back (recurrent). SX-682 is a drug that binds to receptors on some types of immune and cancer cells, inhibiting signaling pathways, reducing inflammation, and allowing other types of immune cells to kill and eliminate cancer cells. Pembrolizumab is a monoclonal antibody that binds to a receptor called PD-1 that is found on the surface of T-cells (a type of immune cell), activating an immune response against tumor cells. Giving SX-682 in combination with pembrolizumab may be more effective at treating patients with metastatic or recurrent non-small cell lung cancer than giving these treatments alone.
This description comes directly from the study's public registry record.
Rebecca Wood · 206-606-6970 · rwood1@fredhutch.org
Always discuss trial participation with your own doctor first.
| Fred Hutch/University of Washington Cancer Consortium | Seattle, Washington, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05570825