Condition: Menopause · Depression · Heart Disease in Women · Sponsor: University of North Carolina, Chapel Hill
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critical public health issue. This research will preliminarily explore whether disruption in two novel stress pathways 1) the renin-angiotensin-aldosterone system (RAAS) and autonomic nervous system (ANS) and their relationship may underlie the link between these illnesses. Findings will provide important insight into potential mechanisms by which depression during perimenopause may increase risk for CVD in midlife women, which will inform potential risk reduction and treatment strategies that can improve health outcomes in this population.
This description comes directly from the study's public registry record.
Margo Nathan, MD · 919-962-9908 · margo_nathan@med.unc.edu
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| University of North Carolina at Chapel Hill | Chapel Hill, North Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05570721