Condition: Non-obstructive Hypertrophic Cardiomyopathy · Sponsor: Morten Steen Kvistholm Jensen
Aim: to compare the treatment effects of Bisoprolol (beta 1 receptor specific beta blocker (BB)) and Verapamil (cardio-specific calcium channel blockers (CCB)) in patients with non-obstructive hypertrophic cardiomyopathy (HCM). Background: Hypertrophic cardiomyopathy (HCM) is characterized by hypertrophy of the left ventricular wall and a hypercontracted state of the sarcomeres. This narrows the left ventricular cavity, but though the left ejection fraction is increased the stroke volume and the cardiac output cannot be fully compensated. The disease manifestations can be mild or develop into severe functional limitations and devastating complications at early age. Dyspnea, chest pain, palpitations and syncope are the most common symptoms, and patients are at risk of supraventricular and ventricular arrhythmias. Arrhythmias and sudden cardiac deaths may precede heart failure symptoms. Patients with symptomatic HCM are treated initially with beta blockers and calcium channel blockers. However, there is limited evidence supporting the effectiveness of this guideline-recommended treatment in HCM. Methods: The study is a multicenter, double-blinded, randomized, placebo-controlled cross-over trial. Patients are randomized in to three 35-days treatment periods with Bisoprolol, Verapamil and Placebo. Each treatment period includes a 7-days up titration period, a 21-days target dose period and a 7-days down titration period. Between treatment periods 45 days treatment pause is allo…
This description comes directly from the study's public registry record.
Morten SK Jensen · 004540145482 · morten.jensen@rm.dk
Louise Bjerregaard · 004540429833 · lbjer@clin.au.dk
Always discuss trial participation with your own doctor first.
| Department of Cardiology, Aarhus University Hospital | Aarhus N, Denmark | Recruiting |
| Department of Cardiology, Odense University Hospital | Odense, Denmark | Recruiting |
| Department of Cardiology, Zealand University Hospital | Roskilde, Denmark | Not Yet Recruiting |
| Department of Cardiology, Regional Hospital Viborg | Viborg, Denmark | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05569382