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Study identifier: NCT05564377 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Condition: Advanced Malignant Solid Neoplasm · Anatomic Stage III Breast Cancer AJCC v8 · Anatomic Stage IV Breast Cancer AJCC v8  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 2
Planned participants2900
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) and have progressed on at least one line of standard systemic therapy or have no standard treatment that has been shown to prolong overall survival may be candidates for these trials. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with some genetic changes or abnormalities (mutations) may benefit from treatment that targets that particular genetic mutation. ComboMATCH is designed to match patients to a treatment that may work to control their tumor and may help doctors plan better treatment for patients with locally advanced or advanced solid tumors.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (483)

University of Alabama at Birmingham Cancer CenterBirmingham, Alabama, United StatesRecruiting
University of South Alabama Mitchell Cancer InstituteMobile, Alabama, United StatesRecruiting
Alaska Women's Cancer CareAnchorage, Alaska, United StatesRecruiting
CTCA at Western Regional Medical CenterGoodyear, Arizona, United StatesRecruiting
Kingman Regional Medical CenterKingman, Arizona, United StatesRecruiting
Mayo Clinic Hospital in ArizonaPhoenix, Arizona, United StatesSuspended
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, Arkansas, United StatesRecruiting
PCR OncologyArroyo Grande, California, United StatesRecruiting
Mercy Cancer Center - CarmichaelCarmichael, California, United StatesRecruiting
Mercy San Juan Medical CenterCarmichael, California, United StatesRecruiting
Epic Care-DublinDublin, California, United StatesActive Not Recruiting
Mercy Cancer Center - Elk GroveElk Grove, California, United StatesRecruiting

+ 471 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05564377