Condition: Gynecologic Cancer · Carcinoma · Uterine Cancer · Sponsor: University of Alabama at Birmingham
Immunotherapy has gained a significant amount of attention recently, but its efficacy as a single agent in gynecological cancers has been disappointing. Pre-clinical evidence supports the combination of using Vascular Endothelial Growth Factors (VEGF) inhibitors with immunotherapy. VEGF inhibitors suppress the activation of tumor-associated macrophages (TAMs) and VEGF has been shown to affect the functional maturation of dendritic cells; therefore, VEGF inhibitors could improve the function of antigen presentation. In this study, Cabozantinib (VEGF inhibitor) and Dostarlimab (immunotherapeutic drug) will be admnistered as a combination to patients with recurrent gynecologic carcinosarcoma.
This description comes directly from the study's public registry record.
Michael Toboni, MD, MSPH · (205) 934-4793 · mdtoboni@uabmc.edu
Margaret A Thomas, MPH · margaretathomas@uabmc.edu
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| O'Neal Comprehensive Cancer Center at UAB | Birmingham, Alabama, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05559879