Condition: Lung Cancer · High-Risk Cancer · Smoking · Sponsor: Gee-Chen Chang
Lung cancer is the leading cause of mortality in the world, and also in Taiwan.Despite the researches and availability in new therapies, it causes the highest mortality and is one of the most preventable cancers as well. Smoking is the most common cause of lung cancer worldwide. Compared to lung cancer in smokers, lung cancer in never-smokers is associated with East Asian ethnicity, female sex, and adenocarcinoma histology. This unique risk group is likely to have distinct molecular drivers, especially EGFR, ALK, and ROS1 mutations.In National Taiwan Cancer Registry data, more than half (53%) of all newly diagnosed lung cancer patients and 93% of female patients are lifelong never-smokers. This scenario is common in East Asia. It is essential to develop a different strategy for screening lung cancer patients with other high-risk profiles. Several risk factors have been identified in never-smoking lung cancer and one of the most important factor is a lung cancer family history (LCFH) in a first-degree relative. Other high-risk occupational or environmental factors include air-pollution exposed occupations (such as traffic policeman and street cleaners) for at least 10 years, cooking index ≥ 110, defined as 2/7 \* days cooking by pan frying, stir frying, or deep frying in one week \* years cooking, cooking without using ventilation, passive smoke exposure, and history of pulmonary tuberculosis or chronic obstructive pulmonary disorders. As described above, three high risk grou…
This description comes directly from the study's public registry record.
GeeChen Chang, MD. PhD · +886-4-24739595 · geechen@gmail.com
Always discuss trial participation with your own doctor first.
| Chung Shan Medical University | Taichung, Taiwan, Taiwan | Recruiting |
| National Taiwan University Hospital Hsin-Chu Branch | Hsinchu, Taiwan | Recruiting |
| Hualien Tzu Chi Hospital | Hualien City, Taiwan | Recruiting |
| E-Da Hospital | Kaohsiung City, Taiwan | Not Yet Recruiting |
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung City, Taiwan | Recruiting |
| Ministry of Health and Welfare Shuang-Ho Hospital | New Taipei City, Taiwan | Not Yet Recruiting |
| National Taiwan University Hospital | Taipei, Taiwan | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05557487