Condition: Alzheimers Disease · Dementia · Alzheimers Disease, Familial · Sponsor: Washington University School of Medicine
The purpose is to evaluate the biomarker effect, safety, and tolerability of investigational study drugs in participants who are known to have an Alzheimer's disease (AD)-causing mutation. Stage 1 will determine if treatment with the study drug prevents or slows the rate of amyloid beta (Aβ) pathological disease accumulation demonstrated by Aβ positron emission tomography (PET) imaging. Stage 2 will evaluate the effect of early Aβ plaque reduction/prevention on disease progression by assessing downstream non-Aβ biomarkers of AD (e.g., CSF total tau, p-tau, NfL) compared to an external control group from the DIAN-OBS natural history study and the DIAN-TU-001 placebo-treated participants.
This description comes directly from the study's public registry record.
Jamie Bartzel · 844-DIANEXR (342-6397) · dianexr@wustl.edu
Ellen Ziegemeier · 844-DIANEXR (342-6397) · dianexr@wustl.edu
Always discuss trial participation with your own doctor first.
| University of Alabama in Birmingham | Birmingham, Alabama, United States | Recruiting |
| University of California San Diego Medical Center | La Jolla, California, United States | Recruiting |
| University of Southern Califonria | Los Angeles, California, United States | Not Yet Recruiting |
| Yale University School of Medicine | New Haven, Connecticut, United States | Recruiting |
| Emory University | Atlanta, Georgia, United States | Recruiting |
| Advocate Lutheran General Hospital | Park Ridge, Illinois, United States | Recruiting |
| Indiana University School of Medicine | Indianapolis, Indiana, United States | Recruiting |
| Washington University in St. Louis | St Louis, Missouri, United States | Recruiting |
| New York University Medical Center | New York, New York, United States | Recruiting |
| University of Pittsburgh | Pittsburgh, Pennsylvania, United States | Recruiting |
| Butler Hospital | Providence, Rhode Island, United States | Recruiting |
| Kerwin Research and Memory Center | Dallas, Texas, United States | Recruiting |
+ 25 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05552157