← Eichor
Study identifier: NCT05551325 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle

Condition: Critical Illness · Sleep Deprivation · Circadian Rhythm Sleep Disorder, Unspecified  ·  Sponsor: Yale University

PhaseNA
Planned participants160
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

More than 5 million patients are admitted to the intensive care unit every year in the United States; most of these patients experience profound sleep and circadian disruption. Promotion of circadian alignment (i.e., alignment of the body's clocks) would make it possible to strategically schedule behaviors such as sleep and eating at normal body clock times, which is predicted to improve sleep quality and metabolic function. This project will test the ability of a sleep chronobundle (i.e., sleep promotion and circadian treatment bundle) to normalize circadian alignment and subsequently test if this realignment also improves sleep and metabolism.

This description comes directly from the study's public registry record.

Talk to the study team

Melissa P Knauert, MD, PhD  ·  203-785-4163  ·  melissa.knauert@yale.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Yale New Haven Hospital Medical Intensive Care Unit (YNHH MICU) at St Raphael's CampusNew Haven, Connecticut, United StatesRecruiting
Yale New Haven Hospital Medical Intensive Care Unit (YNHH MICU) at York StreetNew Haven, Connecticut, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05551325