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Study identifier: NCT05546580 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of Iadademstat and Gilteritinib in Patients With R/R AML With FMS-like Tyrosine Kinase Mutation (FLT3 Mut+)

Condition: Acute Myeloid Leukemia, in Relapse · Acute Myeloid Leukemia Refractory  ·  Sponsor: Oryzon Genomics S.A.

PhasePhase 1
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Iadademstat is being studied as a treatment for subjects with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML) with FMS-like tyrosine kinase mutation (FLT3 mut+). During the trial, iadademstat will be given in combination with gilteritinib, a drug that is already approved to treat patients with FLT3-mutated R/R AML.

This description comes directly from the study's public registry record.

Talk to the study team

Mónica Reale-Vidal, MD  ·  +34 935151313  ·  FRIDA_queries@oryzon.com

Sonia Gutiérrez, MSc  ·  +34 935151313  ·  FRIDA_queries@oryzon.com

Always discuss trial participation with your own doctor first.

Locations (13)

Banner MD Anderson Cancer CenterGilbert, Arizona, United StatesRecruiting
The University of Arizona Cancer Center - North CampusTucson, Arizona, United StatesRecruiting
Sylvester Comprehensive Cancer CenterMiami, Florida, United StatesRecruiting
Miami Cancer InstituteMiami, Florida, United StatesRecruiting
The John Hopkins University School of MedicineBaltimore, Maryland, United StatesRecruiting
Massachusetts General Hospital (MGH)Boston, Massachusetts, United StatesRecruiting
Rutgers, The State UniversityPiscataway, New Jersey, United StatesRecruiting
Icahn School of Medicine at Mount Sinai and Mount Sinai HospitalNew York, New York, United StatesRecruiting
Duke University Medical CenterDurham, North Carolina, United StatesRecruiting
Oregon Health & Science UniversityPortland, Oregon, United StatesRecruiting
Sarah Cannon Research Institute, LLCNashville, Tennessee, United StatesRecruiting
West Virginia UniversityMorgantown, West Virginia, United StatesRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05546580