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Study identifier: NCT05545384 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Immediate Versus Delayed Treatment With Azathioprine or Rituximab in Anti-MOG Antibodies Associated Acute Demyelinating Syndromes in Children: a Randomized Controlled Clinical Trial

Condition: Acute Demyelinating Syndrome  ·  Sponsor: Assistance Publique - Hôpitaux de Paris

PhasePhase 3
Planned participants86
Who can joinAll sexes, 6 Years to 17 Years
Healthy volunteersNo

About this study

Among all non viral encephalitis, myelin oligodendrocytes glycoprotein antibody associated diseases (MOGAD) are the second most frequent diagnosis in children. Risk of relapses varies according to studied cohorts and cognitive and academic difficulties are more and more detected in children without knowing if these sequelae are related to the first attack or relapses. The hypothesis is that earlier treatment would induce reduction of sequelae after the first attack and the number of relapses which would be also associated with a subsequent reduction of disability occurrence on the long term.

This description comes directly from the study's public registry record.

Talk to the study team

Kumaran DEIVA, phD  ·  0145213112  ·  kumaran.deiva@aphp.fr

Domitille MOLINARI  ·  0145217138  ·  domitille.molinari@aphp.fr

Always discuss trial participation with your own doctor first.

Locations (9)

CHU BesançonBesançon, FranceNot Yet Recruiting
CHU BordeauxBordeaux, FranceNot Yet Recruiting
CHU BrestBrest, FranceNot Yet Recruiting
HCL de BronBron, FranceNot Yet Recruiting
Hôpital BicêtreLe Kremlin-Bicêtre, FranceRecruiting
CHRU LilleLille, FranceNot Yet Recruiting
CHU MonptellierMontpellier, FranceNot Yet Recruiting
CHU StrasbourgStrasbourg, FranceNot Yet Recruiting
CHU Toulouse PurpanToulouse, FranceNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT05545384