Condition: Lupus Nephritis · Sponsor: Children's Hospital Medical Center, Cincinnati
The study is a 1-year 2-part double-blinded placebo controlled 2-arm clinical trial. Treatment arms are (1) MMF dosed as per body-surface area (MMFBSA; 600mg/m2 body surface area per dose about every 12 hours) and (2) pharmacokinetically-guided precision-dosing of MMF (MMFPK; MMF dosed twice daily to achieve an area under the concentration-time curve (AUC0-12h) of MPA \>60-70 mg\*h/L. The study goal is to determine the safety and efficacy of MMFPK compared to MMFBSA for the treatment of proliferative LN in subjects 8 to \<21 years.
This description comes directly from the study's public registry record.
Angela Sr CRC · 513-803-2118 · plumm@cchmc.org
Cat Clinical Research Coordinator · 513-636-7299 · Catherine.Robben@cchmc.org
Always discuss trial participation with your own doctor first.
| University of California, San Francisco | San Francisco, California, United States | Recruiting |
| Children's Hospital Colorado | Aurora, Colorado, United States | Recruiting |
| Emory Children's Center | Atlanta, Georgia, United States | Recruiting |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago, Illinois, United States | Recruiting |
| University of Chicago Medicine- Comer Children's | Chicago, Illinois, United States | Recruiting |
| Washington University in St. Louis School of Medicine | St Louis, Missouri, United States | Recruiting |
| Hackensack University Medical Center | Hackensack, New Jersey, United States | Recruiting |
| Hospital for Special Surgery | New York, New York, United States | Recruiting |
| Children's Hospital at Montefiore | New York, New York, United States | Recruiting |
| University of North Carolina at Chapel Hill | Chapel Hill, North Carolina, United States | Recruiting |
| Akron Children's Hospital | Akron, Ohio, United States | Recruiting |
| Cincinnati Children's Hospital Medical Center | Cincinnati, Ohio, United States | Recruiting |
+ 7 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05538208