Condition: Melanoma · Glioma · Thyroid Cancer · Sponsor: Pfizer
The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors. The study will be conducted in two parts: PF-07799544 as a single agent (Phase 1a) and PF-07799544 in combination with another study medicine called PF-07799933 (Phase 1b). Phase 1a is no longer open for enrollment. In Phase1b (noted as "this study"), we are seeking participants who have: * a solid tumor which is metastatic or recurrent (excluding colorectal cancer) * tumor with the mutation (abnormal gene) called "BRAF V600" * received required prior treatment for cancer per cohort assigned. All participants in this study will receive both study medicines. Both study medicines are tablets that are taken by mouth at home twice a day. Participants will receive study medicines until their cancer is no longer responding, unacceptable side effects, or 2 years. Participants may continue to receive study therapy beyond 2 years. We will examine the experiences of people receiving the study medicines. This will help us determine if the study medicines are safe and effective.
This description comes directly from the study's public registry record.
Pfizer CT.gov Call Center · 1-800-718-1021 · ClinicalTrials.gov_Inquiries@pfizer.com
Always discuss trial participation with your own doctor first.
| The Kirklin Clinic of UAB Hospital | Birmingham, Alabama, United States | Recruiting |
| The University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
| University of Alabama at Birmingham - Phase I Clinical Trials Unit | Birmingham, Alabama, United States | Recruiting |
| Highlands Oncology Group, PA | Fayetteville, Arkansas, United States | Recruiting |
| Highlands Oncology Group, PA | Rogers, Arkansas, United States | Recruiting |
| Highlands Oncology Group, PA | Springdale, Arkansas, United States | Recruiting |
| The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate | Los Angeles, California, United States | Recruiting |
| Keck Hospital of USC | Los Angeles, California, United States | Not Yet Recruiting |
| Los Angeles General Medical Center | Los Angeles, California, United States | Not Yet Recruiting |
| USC/Norris Comprehensive Cancer Center | Los Angeles, California, United States | Not Yet Recruiting |
| Keck Medical Center of USC Pasadena | Pasadena, California, United States | Not Yet Recruiting |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco, California, United States | Recruiting |
+ 71 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05538130