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Study identifier: NCT05534321 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease

Condition: Spine Metastases  ·  Sponsor: Baptist Health South Florida

PhasePhase 1/Phase 2
Planned participants74
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Early palliative care has been shown to improve the quality of life and even survival for patients with metastatic cancer. More and more supportive oncology teams in cancer centers now advocate for early integration of radiation therapy (RT) in a patient's palliative management course. While multiple randomized studies have evaluated the efficacy of different RT regimens in the treatment of symptomatic bone lesions, few studies have examined the impact of early, upfront RT for asymptomatic or minimally symptomatic (non- opioid dependent) spine metastases and its efficacy in preventing skeletal-related events (SREs). Since the pathophysiology of spinal metastatic disease is distinct from other bony metastatic disease, the proposed trial seeks to understand whether it is beneficial to patients with minimally symptomatic disease to undergo upfront RT to reduce the risks of SREs and their sequelae, including hospitalizations.

This description comes directly from the study's public registry record.

Talk to the study team

Rupesh R Kotecha, MD  ·  17865962000  ·  rupeshk@baptisthealth.net

Pimental  ·  17865962000

Always discuss trial participation with your own doctor first.

Locations (1)

Miami Cancer Institute at Baptist Health South FloridaMiami, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05534321