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Study identifier: NCT05529927 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder

Condition: Cocaine Use Disorder  ·  Sponsor: Parnassia Addiction Research Centre

PhasePhase 2
Planned participants204
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

In The Netherlands, each year, about 15 thousand people come into treatment because of problems with cocaine use. There is no approved medication for treatment of cocaine addiction and the psychosocial treatment patients receive is not successful for everyone; many return to treatment several times. There is evidence that agonist ("replacement") medications are effective in treating addiction: methadone for heroin addiction; nicotine replacement for smokers. Dexamphetamine is a stimulant medication registered for treatment of ADHD. It may also be effective as agonist treatment for people with cocaine addiction. It will be investigated whether sustained-release dexamphetamine in people with cocaine addiction, participating in routine methadone maintenance treatment for their comorbid opioid use disorder, (1) reduces cocaine use and (2) improves their health and quality of life.

This description comes directly from the study's public registry record.

Talk to the study team

Vincent Hendriks, PhD.  ·  +31651154583  ·  vincent.hendriks@brijder.nl

Tjitske Colenbrander, MsC, MD.  ·  +31616046159  ·  t.colenbrander@brijder.nl

Always discuss trial participation with your own doctor first.

Locations (1)

Brijder Den HaagThe Hague, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT05529927