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Study identifier: NCT05526924 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer

Condition: Head and Neck Cancer · Head and Neck Squamous Cell Carcinoma · Head and Neck Carcinoma  ·  Sponsor: University of Chicago

PhasePhase 1
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, tolerability and maximum tolerated dose of tislelizumab in combination with pamiparib plus chemoradiotherapy (chemotherapy and radiation) in individuals with recurrent head and neck cancer, which means that the person's cancer has come back after treatment. Participation in the study should last for about 15 months while participants receive tislelizumab and chemoradiotherapy with pamiparib. Afterwards, they will return to the clinic for follow up every 4 months for 2 years, every 6 month for the next 2 years, and then once a year for the rest of their life.

This description comes directly from the study's public registry record.

Talk to the study team

Cancer Trial Intake  ·  1-855-702-8222  ·  cancerclinicaltrials@bsd.uchicago.edu

Always discuss trial participation with your own doctor first.

Locations (1)

The University of ChicagoChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05526924