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Study identifier: NCT05525338 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Comparison of Standard Dose Alectinib to Alectinib in Adjusted Dose Based on Alectinib Bloodlevels

Condition: Drug Monitoring · Carcinoma, Non-Small-Cell Lung · Lung Cancer  ·  Sponsor: University Medical Center Groningen

PhasePhase 4
Planned participants196
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The ADAPT ALEC randomized controlled trial (RCT) is performed in patients with Anaplastic Lymphoma Kinase (ALK) positive non-small cell lung cancer (NSCLC). The RCT will compare the use of Therapeutic Drug Monitoring (TDM) and dose increases if alectinib 35 ng/Ml (arm A) with standard of care (arm B).

This description comes directly from the study's public registry record.

Talk to the study team

M.B. Muntinghe-Wagenaar, Msc  ·  +31503616161  ·  adaptalec@umcg.nl

Always discuss trial participation with your own doctor first.

Locations (8)

Gustave RoussyVillejuif, Val-de-Marne, FranceNot Yet Recruiting
Radboud University Medical CenterNijmegen, Gelderland, NetherlandsRecruiting
Maastricht University Medical Center +Maastricht, Limburg, NetherlandsRecruiting
The Netherlands Cancer InstituteAmsterdam, North Holland, NetherlandsRecruiting
Amsterdam University Medical CenterAmsterdam, North Holland, NetherlandsRecruiting
Leiden University Medical CenterLeiden, South Holland, NetherlandsRecruiting
Erasmus Medical CenterRotterdam, South Holland, NetherlandsRecruiting
University Medical Center GroningenGroningen, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT05525338