Condition: Non-Small Cell Lung Cancer · Melanoma · Sponsor: ETOP IBCSG Partners Foundation
The primary objective of the study is to assess the efficacy in terms of CNS-specific PFS of the combination of standard systemic treatment plus SRS vs. standard systemic treatment alone in patients with newly diagnosed and untreated (except for surgery) asymptomatic or oligosymptomatic brain metastases from melanoma or NSCLC. This proposed randomised phase III clinical study addresses one of the most controversial issues in the current approach to patients with brain mets: the timing of SRS in patients eligible for systemic immune checkpoint inhibition or targeted therapy in order to guide therapeutic options as to what strategy allows the best compromise between best survival and best QoL.
This description comes directly from the study's public registry record.
Heidi Roschitzki-Voser, Dr. · +41 31 511 94 18 · heidi.roschitzki@etop.ibcsg.org
Susanne Roux · +41 31 511 94 17 · susanne.roux@etop.ibcsg.org
Always discuss trial participation with your own doctor first.
| Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" | Naples, Italy | Recruiting |
| Instituto Oncologico Veneto IRCCS | Padova, Italy | Not Yet Recruiting |
| Santa Maria della Misericordia Hospital | Perugia, Italy | Recruiting |
| Istituto Nazionale Tumori "Regina Elena" | Roma, Italy | Recruiting |
| Policlinico Umberto 1 | Rome, Italy | Recruiting |
| Azienda ospedaliero-universitaria Senese Siena | Siena, Italy | Recruiting |
| NKI-AVL | Amsterdam, Netherlands | Recruiting |
| Vall Hebron Institute of Oncology (VHIO) | Barcelona, Spain | Recruiting |
| Hospital Puerta de Hierro | Majadahonda, Spain | Recruiting |
| Hospital La Fe | Valencia, Spain | Recruiting |
| Inselspital | Bern, Switzerland | Recruiting |
| Kantonsspital Winterthur | Winterthur, Switzerland | Recruiting |
+ 3 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05522660