Condition: Pediatric Brain Tumor · Pediatric Solid Tumor · Sponsor: Washington University School of Medicine
This is a pilot phase Ib study of the safety of dapagliflozin (in addition to standard of care treatment) for the treatment of pediatric patients with recurrent brain tumors and relapsed/refractory solid tumors. The primary hypothesis is that dapagliflozin is well-tolerated and safe to use in this patient population. The investigators also hypothesize that dapagliflozin will be efficacious as an adjunct to front-line chemotherapy assessed by decreased tumor markers mediated by its pleiotropic metabolic effects.
This description comes directly from the study's public registry record.
Andrew Cluster, M.D. · 314-273-1451 · acluster@wustl.edu
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| Washington University School of Medicine/St. Louis Children's Hospital | St Louis, Missouri, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05521984