Condition: Hepatocellular Carcinoma · Sponsor: National Cancer Centre, Singapore
Hepatocellular carcinoma (HCC) is the 7th most common cancer worldwide but is the 4th deadliest, because diagnosis tend to be late and current systemic therapies are poorly efficacious. Within the same tumour, different parts of the HCC can belong to separate molecular sub-groups. In addition, there is currently no validated predictive biomarkers to help clinicians select the best therapy for an individual patient. This challenge poses an urgent, unmet clinical need. To address this, the multi-disciplinary research program Precision Medicine in Liver Cancer across an Asia-Pacific Network (PLANet 1.0) was conceptualized and successfully conducted from 2016-22. The program uncovered novel insights into the highly heterogeneous molecular landscape of HCC and novel mechanisms, including how HCC reverts to fetal forms to escape the body's immunological defence. These investigations will be continued in PLANet 2.0 and in this new phase, the research team will investigate patients receiving best-in-class therapeutics in 2 investigator-initiated clinical studies (AHCC12 and AHCC13), including Atezolizumab plus Bevacizumab (Atezo+Bev) and Yttrium-90, which allows the research team to collect longitudinal, before and after treatment biosamples and clinical data. These clinical studies will serve as proof-of-concept to the study team's translational findings and allow it to uncover predictive biomarkers which will help clinicians to institute more efficacious and personalized treatmen…
This description comes directly from the study's public registry record.
Pierce CHOW, MD, PhD · +65 6436 8000 · pierce.chow@duke-nus.edu.sg
Always discuss trial participation with your own doctor first.
| National University Hospital Singapore | Singapore, Singapore | Recruiting |
| National Cancer Centre Singapore | Singapore, Singapore | Recruiting |
| Singapore General Hospital | Singapore, Singapore | Recruiting |
| Tan Tock Seng Hospital | Singapore, Singapore | Active Not Recruiting |
| Changi General Hospital | Singapore, Singapore | Recruiting |
| Sengkang General Hospital | Singapore, Singapore | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05516628