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Study identifier: NCT05513872 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Overcoming Nicotine Dependence to Enable Quitting

Condition: Tobacco Use · Smoking Cessation · Smoking Behaviors  ·  Sponsor: Rush University Medical Center

PhasePhase 1/Phase 2
Planned participants780
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly. One novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.

This description comes directly from the study's public registry record.

Talk to the study team

Maritza Esqueda-Medina  ·  312-563-3702  ·  on-deq@rush.edu

Amanda Mathew  ·  312-563-1273  ·  on-deq@rush.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Rush University Medical CenterChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05513872