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Study identifier: NCT05509153 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers

Condition: Huntington Disease  ·  Sponsor: Western Sydney Local Health District

PhasePhase 2
Planned participants160
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

NAC-preHD is a phase II randomized placebo controlled study of oral NAC among premanifest HD gene expansion carriers, with clinical and radiological outcome at three years.

This description comes directly from the study's public registry record.

Talk to the study team

Clement Loy  ·  001164 4 8890 3560  ·  clement.loy@sydney.edu.au

Sarah Samperi  ·  001164 2 8890 9146  ·  sarah.samperi@health.nsw.gov.au

Always discuss trial participation with your own doctor first.

Locations (5)

Westmead HospitalWestmead, New South Wales, AustraliaRecruiting
The University of QueenslandHerston, Queensland, AustraliaNot Yet Recruiting
Calvary Health Care BethlehemParkdale, Victoria, AustraliaNot Yet Recruiting
The Royal Melbourne HospitalParkville, Victoria, AustraliaNot Yet Recruiting
Perron InstituteNedlands, Western Australia, AustraliaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT05509153