Condition: Airway Extubation · Sponsor: Ottawa Hospital Research Institute
Timely and safe extubation in critically ill patients is vitally important as prolonged mechanical ventilation and failed attempts at extubation are associated with increased morbidity, mortality, costs, intensive care unit (ICU) stays, and a risk for aerosolization of COVID-19 to health care providers. A Spontaneous Breathing Trial (SBT) is the current standard of care to assess a patient's readiness for extubation. However, SBTs are performed in various ways and have poor ability to predict successful extubation on their own. There is an urgent need to improve and standardize extubation decision-making. In a prior multicenter study, the investigators showed that decreased respiratory rate variability during SBTs predicted extubation failure better than other predictive indices. The Extubation Advisor (EA) tool combines clinician's assessments of extubation readiness with predictive analytics and risk mitigation strategies for individual patients. In a single centre observational study, the investigators demonstrated the ability to deliver EA reports to the bedside and acceptability of this decision-support tool to respiratory therapists (RTs) and physicians (MDs). The investigators will conduct the Liberation from mechanical ventilation using EA Decision Support (LEADS) Pilot Trial to assess feasibility outcomes. They will include critically ill adults who are invasively ventilated for \>48 hours and are ready to undergo an SBT. Patients in the intervention arm undergo a…
This description comes directly from the study's public registry record.
Andrew JE Seely, MD PhD FRCSC · 613-737-8899 · aseely@toh.ca
Karen Burns, MD MSc FRCPC · karen.burns@unityhealth.to
Always discuss trial participation with your own doctor first.
| Royal Alexandra Hospital | Edmonton, Alberta, Canada | Recruiting |
| St. Boniface Hospital | Winnipeg, Manitoba, Canada | Recruiting |
| Health Sciences Centre Winnipeg | Winnipeg, Manitoba, Canada | Recruiting |
| Kingston Health Sciences Centre | Kingston, Ontario, Canada | Recruiting |
| The Ottawa Hospital | Ottawa, Ontario, Canada | Recruiting |
| Queensway Carleton Hospital | Ottawa, Ontario, Canada | Recruiting |
| Sunnybrook Health Sciences Centre | Toronto, Ontario, Canada | Recruiting |
| Unity Health Toronto - St. Michael's Hospital | Toronto, Ontario, Canada | Recruiting |
| Hotel Dieu de Levis | Lévis, Quebec, Canada | Recruiting |
| Centre hospitalier de l'Université de Montréal (CHUM) | Montreal, Quebec, Canada | Recruiting |
| Hopital de l'Enfant Jesus | Québec, Quebec, Canada | Recruiting |
| Institut universitaire de cardiologie et de pneumologie de Québec | Ste-Foy, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05506904