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Study identifier: NCT05501262 Synced from ClinicalTrials.gov · July 28, 2026
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Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma

Condition: Morton Neuroma  ·  Sponsor: Oregon Health and Science University

PhaseNA
Planned participants32
Who can joinAll sexes, 18 Years to 105 Years
Healthy volunteersYes

About this study

Morton's neuroma is a benign thickening involving the plantar interdigital nerve, most common in middle aged women. Morton's neuroma is one of the most frequent diagnoses seen in the investigators podiatry clinic and is difficult to treat. These lesions cause a burning or shooting pain that can radiate to the toes, or an aching pain in the ball of the foot. The pain is exacerbated with activity and certain footwear greatly limits activity in the involved patient population. Morton's neuroma is first treated conservatively with orthotics. Patients may require further interventions such as steroid injections. The literature reports only a 30% long term resolution of pain with the steroid. Surgical resection has a reported 51-85% success rate with 14-21% rate of complication; recurrent pain, numbness/loss of sensation, and subsequent stump neuromas. Cryoablation is well known to be efficacious for neuropathic pain and has recently been shown in two small studies to be safe and efficacious for treatment of Morton's neuroma. The investigators study will compare outcomes of cryoablation to corticosteroid injection in short- and long-term for treatment of Morton's neuroma that have failed conservative therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Lori L Russell, MSN BSN RN  ·  503-494-7226  ·  watsonlo@ohsu.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Oregon Health Sciences UniversityPortland, Oregon, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05501262