Condition: Von Willebrand Disease, Type 3 · Concomitant VWD and Hemophilia · Sponsor: Bleeding and Clotting Disorders Institute Peoria, Illinois
Von Willebrand Disease (VWD) is the most common inherited bleeding disorder affecting up to 0.1% of the population, is usually characterized by mucocutaneous bleeding, HMB, surgical bleeding or other hemostatic challenges. Severe bleeding events require VWF concentrates administered solely through intravenous access. Emicizumab (Hemlibra) is a monoclonal bispecific antibody developed to bind activated FIX and FX and mimic FVIII cofactor functionality. Hemlibra is administered via subcutaneous injection rather than intravenous infusion. The hypothesis of this study is that Emicizumab is safe and efficacious for prophylaxis in severe VWD and concomitant VWD/hemophilia patients.
This description comes directly from the study's public registry record.
Megan L Woodbury, PhD · 309-692-5337 · meganw@ilbcdi.org
Dayna Lenski, BS · 309-692-5337 · dayna@ilbcdi.org
Always discuss trial participation with your own doctor first.
| The Center for Comprehensive Care and Diagnosis of Inherited Blood Disorders (CIBD) | Orange, California, United States | Recruiting |
| Stanford University: Stanford Children's Health | Redwood City, California, United States | Recruiting |
| University of Miami - Miller School of Medicine | Coral Gables, Florida, United States | Recruiting |
| St. Joseph's Children's Hospital - Center for Bleeding and Clotting Disorders | Tampa, Florida, United States | Recruiting |
| Bleeding and Clotting Disorders Institute (BCDI) | Peoria, Illinois, United States | Recruiting |
| Innovative Hematology, Inc. (IHI) | Indianapolis, Indiana, United States | Recruiting |
| University of Michigan Medical School | Ann Arbor, Michigan, United States | Recruiting |
| Central Michigan University: Children's Hospital of Michigan | Mount Pleasant, Michigan, United States | Recruiting |
| Children's Mercy Hospital | Kansas City, Missouri, United States | Recruiting |
| Penn State College of Medicine | Hershey, Pennsylvania, United States | Recruiting |
| Washington Center for Bleeding Disorders | Seattle, Washington, United States | Recruiting |
| UW Health Comprehensive Program for Bleeding Disorders | Madison, Wisconsin, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05500807