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Study identifier: NCT05499702 Synced from ClinicalTrials.gov · July 28, 2026
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The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction

Condition: Type2diabetes  ·  Sponsor: Adrian Vella

PhasePhase 2
Planned participants20
Who can joinAll sexes, 25 Years to 65 Years
Healthy volunteersNo

About this study

Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction also improves hepatic steatosis and lowers fasting AA. These changes may represent restoration of glucagon's hepatic actions. This experiment will determine whether caloric restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid metabolism in T2DM in comparison to a baseline experiment performed separately in people with T2DM.

This description comes directly from the study's public registry record.

Talk to the study team

Jeanette Laugen  ·  5072558110  ·  Laugen.Jeanette@mayo.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Mayo Clinic in RochesterRochester, Minnesota, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05499702