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Study identifier: NCT05499091 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Functional Study to Indentify Genetic Etiology of Rare Diseases - ORIGIN

Condition: Rare Diseases · Genetic Disease  ·  Sponsor: University Hospital, Angers

PhaseNA
Planned participants1200
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

Next generation sequencing (NGS) allows some better diagnostic results, particularly, in the rare diseases field. At a twenty five percent rate, those exams highlight some variants which are not yet described in human pathology. The relationship between a variant found inside a candidate gene and a pathology, is able to be confirmed by functional studies at a protein level. This study aims to build a biological collection to feed further functional studies to confirm the relationship between NGS identified variants, and the clinical signs and symptoms.

This description comes directly from the study's public registry record.

Talk to the study team

Estelle COLIN, MD-PhD  ·  02.41.35.34.70  ·  escolin@chu-angers.fr

Clément PROUTEAU, MSc  ·  clement.prouteau@chu-angers.fr

Always discuss trial participation with your own doctor first.

Locations (1)

Centre Hospitalo-Universitaire d'AngersAngers, FranceRecruiting

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Source record: clinicaltrials.gov/study/NCT05499091