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Study identifier: NCT05498428 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

Condition: Carcinoma, Non-small-Cell Lung  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 2
Planned participants520
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to assess the anti-tumor activity and safety of amivantamab which will be administered as a co-formulation with recombinant human hyaluronidase PH20 (rHuPH20) (subcutaneous co-formulation \[SC-CF\]) in combination treatment (all cohorts except Cohort 4) and to characterize the safety of amivantamab SC-CF (Cohort 4).

This description comes directly from the study's public registry record.

Talk to the study team

Study Contact  ·  844-434-4210  ·  Participate-In-This-Study1@its.jnj.com

Always discuss trial participation with your own doctor first.

Locations (110)

University of California at San DiegoLa Jolla, California, United StatesRecruiting
University of California IrvineOrange, California, United StatesRecruiting
Stanford Cancer InstituteStanford, California, United StatesRecruiting
Johns Hopkins Office of Capital Region Research - Sibley Memorial HospitalWashington D.C., District of Columbia, United StatesRecruiting
Baptist Lynn Cancer InstituteBoca Raton, Florida, United StatesCompleted
Mount Sinai Medical CenterMiami Beach, Florida, United StatesRecruiting
AdventHealthOrlando, Florida, United StatesRecruiting
H. Lee Moffitt Cancer & Research InstituteTampa, Florida, United StatesCompleted
University of Kansas Cancer CenterWestwood, Kansas, United StatesRecruiting
Sidney Kimmel Cancer Center - Bayview CampusBaltimore, Maryland, United StatesRecruiting
Boston Medical CenterBoston, Massachusetts, United StatesRecruiting
Washington University School Of MedicineSt Louis, Missouri, United StatesRecruiting

+ 98 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05498428