Condition: HPV · Human Papilloma Virus · Human Immunodeficiency Virus · Sponsor: University of British Columbia
There are very little data on human papillomavirus (HPV) vaccination among the 18 million women living with HIV (WLWH) globally, who constitute a population most vulnerable to HPV and the resultant cervical cancer. Particularly, there are no data to date on reduced-dose schedules of nonavalent HPV (9vHPV) vaccination in WLWH and there are very little data on the 9vHPV vaccine in this population overall. It is critical to examine the 9vHPV vaccine in WLWH now because the quadrivalent HPV (4vHPV) vaccine has been discontinued. Additionally, in order to reach the World Health Organization's global goal of cervical cancer elimination, we must determine the role of various HPV prevention strategies in this important population including reduced vaccine dosing which can drastically increase the feasibility of HPV vaccination programs globally. This randomized clinical trial will enrol WLWH aged 18-45 from across Canada who have not previously received an HPV vaccine. Participants will be randomized 1:1 to receive 3 doses of 9vHPV vaccine at the routine vaccine schedule of 0/2/6 months or 2 doses at an expanded schedule of 0/6 months with a third dose at month 12 to adhere to current recommendations for WLWH. We will compare the immune response generated to two versus three doses of 9vHPV vaccine and will follow participants for 2 years to examine the immune response over time. This study, which builds upon our team's prior work on HPV vaccination in WLWH, will determine whether t…
This description comes directly from the study's public registry record.
Deborah Money, MD · 6048752194 · deborah.money@ubc.ca
Always discuss trial participation with your own doctor first.
| Positive Health Services - Fraser Health | Surrey, British Columbia, Canada | Not Yet Recruiting |
| University of British Columbia | Vancouver, British Columbia, Canada | Recruiting |
| Health Sciences Centre | Winnipeg, Manitoba, Canada | Not Yet Recruiting |
| Hamilton Health Sciences | Hamilton, Ontario, Canada | Not Yet Recruiting |
| St. Michael's Hospital | Toronto, Ontario, Canada | Recruiting |
| Toronto General Hospital | Toronto, Ontario, Canada | Recruiting |
| Centre Hospitalier Universitaire Sainte-Justine | Montreal, Quebec, Canada | Recruiting |
| McGill University Health Centre | Montreal, Quebec, Canada | Not Yet Recruiting |
| Centre Hospitalier de l'Université Laval | Québec, Quebec, Canada | Recruiting |
| Regina General Hospital | Regina, Saskatchewan, Canada | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05495906