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Study identifier: NCT05495295 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

First-in-human Trial of PhOx430, a First-in-class Acetylglucosaminyltransferase V Inhibitor, in Advanced Solid Tumours

Condition: Malignant Tumor · Advanced Solid Tumor · Glioblastoma Multiforme  ·  Sponsor: Phost'In Therapeutics

PhasePhase 1
Planned participants149
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The PhAST Trial is an adaptive first-in-human clinical trial of the acetylglucosaminyltransferase V inhibitor PhOx430 in patients with advanced solid tumours conceived and designed with the contribution of the Gianni Bonadonna Foundation, a non-profit academic research institution aimed at promoting therapeutic innovation in oncology.. The trial includes two parts, a dose escalation phase which will enroll patients with non-selected tumour types, followed by a cohort expansion phase in selected tumour types.

This description comes directly from the study's public registry record.

Talk to the study team

Karine Chorro, Mrs.  ·  +33 (0) 4 11 93 77 51  ·  phast@phostin.com

Always discuss trial participation with your own doctor first.

Locations (4)

Institut du Cancer de MontpellierMontpellier, FranceRecruiting
Fondazione IRCCS Istituto Nazionale dei TumoriMilan, ItalyRecruiting
IRCCS Ospedale San RaffaeleMilan, ItalyRecruiting
Azienda Unità Sanitaria Locale - IRCCS di Reggio EmiliaReggio Emilia, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT05495295