Condition: Wilson's Disease · Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Heart damage by copper accumulation has been reported in Wilson's Disease. However, the disease epidemiology is still poorly understood. A number of studies on pediatric populations have not shown any significant cardiac involvement apart from early dysautonomia. This could suggest that the clinical manifestations related to the copper accumulation in the heart appears with the duration of the disease. Case-control studies on adult populations have highlighted various electrocardiographic (ECG) abnormalities more frequent in patients with Wilson's Disease than in healthy volunteers, but all these studies involved small number of patients (maximum 60). The hypothesis is that there is cardiac involvement in Wilson's Disease, requiring screening, follow-up and appropriate support.
This description comes directly from the study's public registry record.
Amélie YAVCHITZ · 01 48 03 64 54 · ayavhitz@for.paris
Aurélia POUJOIS · 01 48 30 66 56 · apoujois@for.paris
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| Fondation Adolphe de Rothschild | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05493605