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Study identifier: NCT05488431 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

Condition: Dyslipidemias · Cardiovascular Diseases · HIV Infections  ·  Sponsor: Priscilla Hsue, MD

PhasePhase 2
Planned participants121
Who can joinAll sexes, 40 Years to no upper limit
Healthy volunteersNo

About this study

This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by FDG-PET/CT, lipids, inflammation, immune activation, cardiometabolic indices, and non-calcified plaque (NCP) in the coronary arteries (assessed by coronary CT angiography, CCTA). This trial will be enrolled at UCSF and UCLA. Collaborators at Massachusetts General Hospital (MGH) will serve as the core facility for imaging.

This description comes directly from the study's public registry record.

Talk to the study team

Marta Levkova  ·  628-206-8037  ·  marta.levkova@ucsf.edu

Always discuss trial participation with your own doctor first.

Locations (3)

UCLA Center for Clinical AIDS Research and Education (CARE)Los Angeles, California, United StatesRecruiting
San Francisco General HospitalSan Francisco, California, United StatesRecruiting
UT Health HoustonHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05488431