Condition: Statin Treatment for Primary Prevention · Sponsor: Insel Gruppe AG, University Hospital Bern
Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older adults (aged ≥70 years) without CVD are uncertain, particularly for those with multimorbidity. To better target adults who may benefit from statins in primary prevention, coronary artery calcium (CAC) measurement is rapidly increasing in clinical use and is recommended for risk re-classification in some guidelines. Older patients with a high burden of subclinical atherosclerosis might benefit from continuing statins to prevent CV outcomes, but this hypothesis has not been rigorously tested in randomized clinical trials (RCTs). To address these questions, the investigators conduct a RCT in 500 multimorbid adults ≥70 years old taking statins for primary prevention who will be randomized to statin continuation vs. statin discontinuation, and measure baseline CAC to determine if the risk of a composite outcome of CV events and all-cause mortality after statin discontinuation differs among those with evidence of subclinical atherosclerosis at baseline as measured by CAC.
This description comes directly from the study's public registry record.
Manuel R Blum, MD, MSc · +41 31 632 21 11 · manuel.blum@insel.ch
Nicolas Rodondi, MD, MAS · +41 31 632 00 69 · nicolas.rodondi@insel.ch
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| University Hospital of Bern, University of Bern | Bern, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05482399