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Study identifier: NCT05477589 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Studying Conditioning Regimen In Pediatric Transplantation - AML , SCRIPT-AML

Condition: Acute Myeloid Leukemia (AML) in Remission · Stem Cell Transplantation  ·  Sponsor: Vastra Gotaland Region

PhasePhase 3
Planned participants170
Who can joinAll sexes, N/A to 18 Years
Healthy volunteersNo

About this study

It is a randomized phase 3 study comparing two conditioning regimens in children with Acute Myeloid Leukemia, AML, undergoing allogenic stem cell transplantation. The primary aim is to investigate if a conditioning regimen containing one alkylator (Bu) combined with two antimetabolites (Clo and Flu) results in superior 2-year acute grade III to IV-free, chronic non-limited GvHD-free, relapse free survival than a conditioning regimen combining three alkylating agents (BuCyMel)

This description comes directly from the study's public registry record.

Talk to the study team

Karin Mellgren, Prof. MD  ·  +46 (0)31 3421000  ·  karin.mellgren@vgregion.se

Anna M Schröder Håkansson, RN  ·  +46 (0) 761141327  ·  anna.schroder_hakansson@vgregion.se

Always discuss trial participation with your own doctor first.

Locations (17)

L'Hôpital Universitaire des Enfants Reine Fabiola (HUDERF)Brussels, BelgiumNot Yet Recruiting
Cliniques Universitaires Saint-Luc (CUSL)Brussels, BelgiumNot Yet Recruiting
Department of Pediatric Hematology, Oncology and SCT, Ghent University HospitalGhent, BelgiumNot Yet Recruiting
University Hospital LeuvenLeuven, BelgiumNot Yet Recruiting
Centre Hospitalier Régional de la Citadelle (CHR)/CHU LiègeLiège, BelgiumNot Yet Recruiting
Paediatric Stem Cell Transplant and Immune Deficiency, Department of Pediatric and Adolescent Medicine, Section 4072, Rigshospitalet University Hospital of CopenhagenCopenhagen, DenmarkRecruiting
Division of Hematology, Oncology, and Stem Cell Transplantation, The New Children's Hospital, Helsinki University HospitalHelsinki, FinlandRecruiting
Department of Pediatrics and Adolescent Medicine, Hong King Children's HospitalHong Kong, Hong KongNot Yet Recruiting
Schneider Children's Medical Center of IsraelPetah Tikva, IsraelNot Yet Recruiting
Vilnius University Hospital Santaros Klinikos Center for Pediatric Oncology and HematologyVilnius, LithuaniaNot Yet Recruiting
Princess Máxima Center for Pediatric OncologyUtrecht, NetherlandsRecruiting
Department of Pediatric Hematology and Oncology, Oslo University HospitalOslo University HospitalOslo, NorwayRecruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05477589