Condition: Cannabis Use Disorder · Healthy · Sponsor: Yale University
The main purpose of this study is to determine whether hippocampal synaptic vesicle density estimated by hippocampal \[11C\]APP-311/\[11C\]UCB-J binding in individuals diagnosed with cannabis use disorder (CUDs) improves with at least 4 weeks of confirmed abstinence from cannabis, in comparison to healthy controls (HCs). Furthermore, any change in synaptic vesicle density will be placed in functional context by measuring verbal memory, which is sensitive to hippocampal function, before and after at least 4 weeks of confirmed abstinence. Finally, the relationship between hippocampal \[11C\]UCB-J binding in CUDs with measures of cannabis exposure (e.g., age of initiation, cumulative lifetime dose) will be explored.
This description comes directly from the study's public registry record.
Shannon Zeilman · 203-974-7822 · shannon.zeilman@yale.edu
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| Yale University School of Medicine | New Haven, Connecticut, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05472818